| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082079 | Drug Discovery Today: Disease Models | 2013 | 5 Pages |
Abstract
Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.
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Authors
Sayaka Watanabe, Fan-Yan Wei, Kazuhito Tomizawa,