| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082130 | Drug Discovery Today: Disease Models | 2011 | 7 Pages |
Abstract
The matrix metalloproteinases are a family of matrix degrading enzymes that are important regulators of extracellular matrix remodelling and cellular function. This article presents a review of the mechanisms through which MMPs are regulated including transcriptional, post-transcriptional and post-translational events. Regulation of MMPs within the cardiovascular system and their contribution to physiological and pathological events will be discussed.
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Authors
Jennifer L. Gorman, Eric Ispanovic, Tara L. Haas,