| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082181 | Drug Discovery Today: Disease Models | 2008 | 8 Pages |
Abstract
Because of their outbred nature and close genetic and immunological proximity to humans, non-human primates offer unique models for translational research into autoimmune-mediated inflammatory disorders. This review discusses non-human primate models of multiple sclerosis (MS), a progressive neurological disorder with a high unmet need for effective treatment. These models can help to bridge the gap between rodent experimental autoimmune encephalomyelitis (EAE) models and patients, which is a main cause of the present high attrition rate of new treatments.
Section editors:Margreet Jonker, Michel Vierboom and Bert 't Hart – Biomedical Primate Research Centre BPRC, Rijswijk, The Netherlands
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Authors
Bert A. ’t Hart, Jeffrey J. Bajramovic,