Models of IgA nephropathy

Human IgA nephropathy (IgAN) is a common, progressive glomerular disease of unknown pathogenesis. The majority of patients present with IgAN as primary disease, but it can also be secondary to inflammatory or infectious diseases. Numerous animal models have been developed to uncover the IgAN pathogenesis but they typically reflect only partial aspects of the full human disease spectrum. There is still a considerable demand for a reliable and widely accepted IgAN model that can be used for preclinical drug development.