Impulsivity in animal models for drug abuse disorders

Different conceptual frameworks have been generated to explain substance abuse; of relevance to this article, dysfunction of impulse control systems that are required for avoiding or stopping drug-seeking and -taking may play a key role in addiction. This review summarizes work in animal models that explains the pervasive association between impulse control and substance abuse. It further underscores the concept that impulse control may be a crucial target for pharmacological intervention in the treatment of addictions and suggests that further developments in animal models for impulsivity may be useful in expanding our understanding and treatment of drug abuse.

Section editors:Nigel Maidment and Niall Murphy – Hatos Center for Neuropharmacology, UCLA, Los Angeles, CA, USAM. Foster Olive – Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA