| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082348 | Drug Discovery Today: Disease Models | 2006 | 9 Pages |
Abstract
The heart is highly dependent on aerobic metabolism. Given the widespread occurrence of coronary atherosclerosis in the human, myocardial ischemia is a huge clinical problem. Myocardial ischemic is a molecular disease of cardiomyocytes, but also, as a consequence of reduced heart function, becomes a disease of the whole organism. Experimental models range from large animal models designed to mimic the human clinical situation, to gene modified mice, isolated hearts and cell cultures.
Section editor:Steve Pogwizd – University of Illinois at Chicago, Chicago, USA
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Authors
Kirsti Ytrehus,