| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082395 | Drug Discovery Today: Disease Models | 2007 | 6 Pages |
Abstract
Despite the recent improvement in the efficacy of medical treatments, heart failure remains the leading cause of mortality in the western world. Heart failure is a complex syndrome characterized by functional and structural abnormalities of the myocardium. Alteration of Ca2+ homeostasis is thought to be a crucial mechanism underlying heart failure pathogenesis. This review focuses on the experimental models that have recently been developed to investigate the role of Ca2+ in heart failure.
Section editors:Rahul Kakkar and Richard T. Lee – Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA, USA
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Authors
Marco Mongillo, Andrew R Marks,