Article ID Journal Published Year Pages File Type
2082483 Drug Discovery Today: Technologies 2013 7 Pages PDF
Abstract

14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein–protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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