| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082525 | Drug Discovery Today: Technologies | 2013 | 9 Pages |
Abstract
Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC chemokine receptor 4, their contribution to the understanding of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.
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Authors
Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger,