| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082569 | Drug Discovery Today: Technologies | 2012 | 6 Pages |
Abstract
The blood–brain barrier presents a significant hurdle in CNS drug development. Blood-to-brain delivery by effectively crossing this barrier allows therapeutics to reach a large area of the brain. Over the past decades several drug delivery technologies have been developed, some more successful than others, which we hold against 10 key development criteria. Adhering to these criteria will allow a more successful development of therapeutics for patients with devastating brain diseases.
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Authors
Pieter J. Gaillard, Corine C. Visser, Chantal C.M. Appeldoorn, Jaap Rip,