| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082598 | Drug Discovery Today: Technologies | 2010 | 8 Pages |
Abstract
Structure-based virtual screening generally relies on three-dimensional pharmacophore methods or docking approaches, which are applied either separately or in combination in screening campaigns. Detection of the best candidates among the compounds that match a pharmacophore model or fit into a binding pocket constitutes the main challenge. Awareness of the advantages and limitations of the different approaches is essential for their successful application in virtual screening.
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Authors
Michael Hein, David Zilian, Christoph A. Sotriffer,