Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2082610 | Drug Discovery Today: Technologies | 2008 | 8 Pages |
Abstract
The routine application of high-throughput screening (HTS) of compound files has shifted the bottleneck in target-based drug discovery from hit identification to hit qualification because not all hit molecules have the potential to become leads and drug candidates. Biophysical, label-free detection techniques are generic, direct and information-rich, and there is a growing interest in applying these during hit qualification. Some techniques have seen a rapid development toward enhanced sensitivity and throughput and their application to primary screening is within reach.
Section editors:Phil Gribbon – European ScreeningPort, Hamburg, GermanyKelvin Lam – Harvard University, Cambridge, MA, USA
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Authors
Jan Kahmann, Dirk Winkler, Thomas Hesterkamp,