Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2082630 | Drug Discovery Today: Technologies | 2013 | 6 Pages |
Abstract
Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease which affects specific muscles. No pharmacological treatments are currently available for OPMD. In recent years, genetically tractable models of OPMD – Drosophila and Caenorhabditis elegans – have been generated. Although these models have not yet been used for large-scale primary drug screening, they have been very useful in candidate approaches for the identification of potential therapeutic compounds for OPMD. In this brief review, we summarize the data that validated active molecules for OPMD in animal models including Drosophila, C. elegans and mouse.
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Authors
Aymeric Chartier, Martine Simonelig,