| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082703 | Drug Discovery Today: Technologies | 2006 | 8 Pages |
Abstract
Interactions between proteins play a pivotal role in virtually all cellular processes, and many of these interactions represent interesting targets for drug development. Among the wide array of interactor-hunting technologies that has emerged, genetic two-hybrid methods account for a large amount of the currently available interaction data and is being successfully applied in interactome-scale mapping projects. Reverse two-hybrid approaches have been developed that allow selected interactions to be assayed for disrupting compounds.
Section editors:Anne-Claude Gavin – EMBL, Heidelberg, GermanyAlbert Heck – Utrecht University, Utrecht, Germany
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Authors
Sam Lievens, Irma Lemmens, Tony Montoye, Sven Eyckerman, Jan Tavernier,