| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082762 | Drug Discovery Today: Technologies | 2010 | 7 Pages |
Abstract
Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules. These assays provide a new dimension for elucidating receptor biology and for facilitating drug discovery.
Section editors:Terence Kenakin – Glaxo Smith Kline, Systems Research 3-2104.2B, Research Triangle Park, NC 27709, USAAlan Wise – Edinburgh, UK
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Ye Fang,