Assessment of drug-induced immunotoxicity in animal models

With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

Section editors:Charles L. Crespi – BD Biosciences, Woburn, MA, USAKenneth Thummel – University of Washington, Seattle, WA, USA