Adopting orphaned drugs: developing multidrug regimens using generic drugs

We define ‘orphaned drugs’ as those proven drugs that have been abandoned because of a perceived inability to develop them commercially for new indications. Using a hierarchical-network (‘HiNET’) algorithm applied to a disease of interest, we identify the probable drug candidates for repurposing based on the similarity principle. Here, we describe an approach for selection and commercial development of multidrug regimens using innovative analytical and business models.