Article ID Journal Published Year Pages File Type
2082903 Drug Discovery Today: Therapeutic Strategies 2010 6 Pages PDF
Abstract

The prevalence of age-related pathologies such as neurodegenerative disease and diabetes type II has increased with rise in average age of people. Finding antiaging molecules is necessary to prevent or delay the alterations taking place in age which are manifested as age-associated illnesses. Currently, dietary restriction (DR) is one of the most effective antiaging interventions. Thus, the biochemical pathways involved in DR lifespan increase are under intensive investigation. Sirtuin 1 and mTOR (mammalian target of rapamycin) are two well characterized antiaging pathways. Resveratrol constitutes a natural compound which mimics the effects of DR with potential application on age-associated diseases and thus as antiaging therapy.

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