| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2083049 | Drug Discovery Today: Therapeutic Strategies | 2007 | 5 Pages |
Abstract
The worldwide obesity epidemic has prompted renewed interest in understanding the mechanisms of energy homeostasis. Neural and endocrine signals from gut to brain are thought to play a vital role in the short-term regulation of appetite. Several gut hormones including glucagon-like-peptide-1, oxyntomodulin (OXM), peptide YY (PYY) and pancreatic polypeptide (PP) act as satiety signals, whilst ghrelin acts as a hunger hormone by increasing appetite. Modulation of gut hormones could provide an effective long-term therapy for the treatment of obesity.
Section editors:Ramakanth Sarabu and Jefferson W. Tilley – Roche Research Center, Nutley, NJ 07110, USA
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Authors
Barbara M. McGowan, Stephen R. Bloom,