| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2083333 | European Journal of Pharmaceutics and Biopharmaceutics | 2015 | 4 Pages |
•Hydrophobic Asarone was loaded in mesoporous silica SBA-15 by SC-CO2 technology.•Asarone presented as stable amorphous state in SBA-15.•Dissolution and bioavailability of Asarone were significantly improved.
The aim of this study was to load amorphous hydrophobic drug into ordered mesoporous silica (SBA-15) by supercritical carbon dioxide technology in order to improve the dissolution and bioavailability of the drug. Asarone was selected as a model drug due to its lipophilic character and poor bioavailability. In vitro dissolution and in vivo bioavailability of the obtained Asarone-SBA-15 were significantly improved as compared to the micronized crystalline drug. This study offers an effective, safe, and environmentally benign means of solving the problems relating to the solubility and bioavailability of hydrophobic molecules.
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