| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2083837 | European Journal of Pharmaceutics and Biopharmaceutics | 2014 | 5 Pages |
•Photophysics of cinacalcet and naproxen entrapped within liposomes has been studied.•It has revealed an efficient inclusion of the photoactive drugs inside liposomes.•Increasing in the triplet lifetimes of drugs inside liposomes has been observed.•Laser flash photolysis is an appropriate tool to evaluate drug encapsulation.
The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer evaporation and characterized by transmission electron microscopy, cryoscopy scanning electron microscopy and dynamic light scattering. Steady state and time-resolved fluorescence experiments showed similar spectra, emission quantum yields, singlet energies and lifetimes for the selected drugs, outside and inside liposomes. By contrast, laser flash photolysis experiments revealed an important enhancement of the triplet lifetimes for entrapped drugs inside liposomes, indicating the spatial confinement existing in the microenvironment prevailing in these biomimetic entities. Thus, this photophysical property shows potential as a non-invasive, direct and valuable tool to monitor encapsulation of photoactive drugs and to probe the intraliposome environment. In addition, it provides a new quantitative indicator of the capability of liposomes to act as drug carriers.
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