Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats

Article ID	Journal	Published Year	Pages	File Type
2084011	European Journal of Pharmaceutics and Biopharmaceutics	2012	9 Pages	PDF

Abstract

A remote-loading method in the presence of phenylboronic acid (PBA) was developed for stably encapsulating 3-deazaneplanocin A (DZNep) inside pegylated liposomes through forming a transient PBA-DZNep complex.

Keywords

PBA reverse-phase evaporation Cmax NUS PBS 3-Deazaneplanocin A MLV MRT REV LLOQ RSD EZH2 AUC0–∞DZNep LC–MS/MS VSs Nucleoside analogs internal standard Phenylboronic acid Ultraviolet relative standard deviation standard deviation Tem ANOVA one-way analysis of variance clearance enhancer of zeste homolog 2 apparent volume of distribution at steady state maximum plasma concentration National University of Singapore mononuclear phagocyte system coefficient of determination Pharmacokinetics Reversed-phase PEGylated liposomes small unilamellar liposomes SUV lower limit of quantitation Phosphate-buffered saline MAC Mean residence time Transmission electron microscopy MPs body weight PEG membrane attack complex Multilamellar log Kow creatinine liquid chromatography coupled with tandem mass spectrometry

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Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats

Authors

Feng Sun, Jian Li, Qiang Yu, Eli Chan,