| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2084077 | European Journal of Pharmaceutics and Biopharmaceutics | 2011 | 7 Pages |
Abstract
GlycoPEGylation postpones the calcium induced thermal destabilisation of recombinant human factor VIIa. Increasing the CaCl2 concentration from 10Â mM to 35Â mM resulted in a decrease in the apparent unfolding temperature, Tm, of rFVIIa, whereas the concentration of CaCl2 has to be raised to 100Â mM in order to see the same effect on the GlycoPEGylated rFVIIa compounds.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Bitten Plesner, Peter Westh, Anders D. Nielsen,