| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2084959 | European Journal of Pharmaceutics and Biopharmaceutics | 2007 | 10 Pages |
The water vapour sorption–desorption behaviour of graft copolymers (hydroxypropylstarch–methyl methacrylate -HSMMA- and carboxymethylstarch–methyl methacrylate -CSMMA-) synthetised by free-radical polymerisation and alternatively dried by oven (OD) or freeze-drying (FD) techniques was investigated in a previous paper. The aim of the present study was to analyse the influence of the amount and distribution of water molecules on the flow and compaction characteristics of this family of methyl methacrylate–starch copolymers. Products were stored at constant temperature (25 °C) and different relative humidity conditions (RH). Flow properties of the powdered materials were evaluated using glass and stainless-steel funnels and the densification behaviour was studied in detail by means of Heckel treatment and compression parameters. Results revealed that the storage at 25–50% RH was the optimum condition relating flowability for HSMMA and OD-CSMMA copolymers. At higher RH values, the flow characteristics worsened, due to an increment in cohesive forces. Compaction experiments showed that the 25–50% RH range improved also the compression performance of the copolymers, due to increasing powder compressibility and reduced compact relaxation. Under these circumstances, absorbed water might act as plasticiser and adsorbed water as lubricant.
