| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2092678 | Microbiological Research | 2010 | 9 Pages |
Abstract
SummaryDoxorubicin (DXR), produced by Streptomyces peucetius ATCC 27952, exhibits potent antitumor activity against various cancer cell lines. Considerable time has lapsed since the biosynthesis of DXR and its overproduction was first summarized. Based on biosynthetic studies and product analysis, various factors affecting its production by the parental strain, S. peucetius ATCC 27952, are reviewed to better circumvent any bottlenecks in DXR production, thereby providing ideas to genetically engineered industrial strains of S. peucetius.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Sailesh Malla, Narayan Prasad Niraula, Bijay Singh, Kwangkyoung Liou, Jae Kyung Sohng,