| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2093363 | Stem Cell Reports | 2014 | 13 Pages |
•3D retina was formed from ESCs/iPSCs using retinoic acid receptor antagonist•ESC/iPSC retina developed a structured layer of photoreceptors in rd1 host mice•Transplanted photoreceptors formed complete inner and outer segments•Transplanted photoreceptors morphologically made synapses with host bipolar cells
SummaryIn this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a “proof of concept” for retinal sheet transplantation therapy for advanced retinal degenerative diseases.
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