Article ID Journal Published Year Pages File Type
2100486 Best Practice & Research Clinical Haematology 2010 6 Pages PDF
Abstract

FLT3 inhibition has been a goal of acute myeloid leukemia (AML) therapy since FLT3 mutations were discovered to have a role in AML. Several FLT3 inhibitors have been developed in the last several years, beginning with less potent, less selective agents. The newer FLT3 inhibitors appear to be more potent in vivo and have shown more promise than the older agents in monotherapy trials.

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