| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2100727 | Best Practice & Research Clinical Haematology | 2009 | 5 Pages |
Abstract
It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.
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Authors
Kenneth MD, Helen M. (Distinguished Professor, Chair),