Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2101012 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2010 | 10 Pages |
Abstract
Protein kinase D is a novel family of serine/threonine kinases and diacylglycerol receptors that belongs to the calcium/calmodulin-dependent kinase superfamily. Evidence has established that specific PKD isoforms are dysregulated in several cancer types, and PKD involvement has been documented in a variety of cellular processes important to cancer development, including cell growth, apoptosis, motility, and angiogenesis. In light of this, there has been a recent surge in the development of novel chemical inhibitors of PKD. This review focuses on the potential of PKD as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of PKD inhibitors.
Keywords
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Courtney R. LaValle, Kara M. George, Elizabeth R. Sharlow, John S. Lazo, Peter Wipf, Q. Jane Wang,