Article ID Journal Published Year Pages File Type
2101175 Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2007 26 Pages PDF
Abstract

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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