Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2103182 | Biology of Blood and Marrow Transplantation | 2011 | 4 Pages |
Abstract
Donor-specific antihuman leukocyte antigen antibodies (DSHA) have been clearly implicated in graft rejection in solid organ transplantation. Their role in allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains unclear. We summarize here evidence supporting a role for DSHA in graft failure in animal models of allo-HSCT and in clinical settings whenever no full HLA matching occurs.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Daniele Focosi, Alessandra Zucca, Fabrizio Scatena,