Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2103232 | Biology of Blood and Marrow Transplantation | 2013 | 5 Pages |
Abstract
The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell–mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.
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Authors
Isao Tawara, Chen Liu, Hiroya Tamaki, Tomomi Toubai, Yaping Sun, Rebecca Evers, Evelyn Nieves, Nathan Mathewson, Gabriel Nunez, Pavan Reddy,