| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2105210 | Biology of Blood and Marrow Transplantation | 2006 | 4 Pages |
Abstract
Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4+ and CD8+ T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.
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Authors
Stanley R. Riddell, Marie Bleakley, Tetsuya Nishida, Carolina Berger, Edus H. Warren,