Article ID Journal Published Year Pages File Type
2107526 Cancer Cell 2010 14 Pages PDF
Abstract

SummaryTwo vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.

► DAAP simultaneously binds VEGF-A and angiopoietins, and blocks their actions ► DAAP effectively suppresses tumor angiogenesis, metastasis and vascular leakage ► DAAP is superior to VEGF-Trap plus Tie2-Fc in blocking tumor growth and metastasis ► Ang-2 is a therapeutic target to control tumor angiogenesis and vascular leakage

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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