| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2108403 | Cancer Cell | 2008 | 12 Pages |
Abstract
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
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Authors
Francesca Bernassola, Michael Karin, Aaron Ciechanover, Gerry Melino,