Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2109388 | Cancer Epidemiology | 2009 | 6 Pages |
Abstract
Background: Lost or downexpression of the gene deleted in liver cancer 1 (DLC1) has been implicated in the development of hepatocellular carcinoma (HCC). We examined the relationship between DLC1 polymorphisms and HCC risk among Chinese. Methods: Three DLC1 polymorphisms, Ex11Â +Â 255TÂ >Â G (rs3739298), Ex11-620GÂ >Â A (rs532841) and IVS19Â +Â 108CÂ >Â T (rs621554), were genotyped in 434 patients with HCC and 480 controls by PCR-RFLP. The associations with the susceptibility to HCC were evaluated while controlling for confounding factors. Results: We observed significantly increased susceptibility to HCC for the C/C genotype compared with T/T of IVS19Â +Â 108CÂ >Â T in the HBV carriers (ORÂ =Â 2.95, 95% CI, 1.65-5.26, PÂ <Â 0.001). Compared with the haplotype G-A-T (in order of Ex11Â +Â 255TÂ >Â G, Ex11-620GÂ >Â A and IVS19Â +Â 108CÂ >Â T), the haplotype T-G-C was also significantly associated with an increased susceptibility to HCC among HBV carriers (ORÂ =Â 2.16, 95% CI, 1.08-4.35, PÂ =Â 0.009). The stratified analysis indicated no modification of the confounding factors on the increased susceptibility to HCC related to the DLC1 polymorphism/haplotype. Conclusions: Our findings suggest that DLC1 genetic polymorphism or haplotype play a role in mediating the susceptibility to HBV-related HCC.
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Authors
Xiaoqun Dong, Gangqiao Zhou, Yun Zhai, Hongxing Zhang, Hao Yang, Lianteng Zhi, Xiumei Zhang, Jiayou Chu, Fuchu He,