Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2109758 | Cancer Genetics | 2016 | 5 Pages |
Abstract
Chromosomal abnormalities at 14q11, which encodes the T-cell receptor α and δ chain genes, are generally specific for T-cell malignancies, and are rarely reported in other malignancies. We report a novel t(11;14)(p13;q11.2) in a patient with myelofibrosis (MF) following polycythemia vera (PV). This 55-year-old male developed post-PV MF 12 years after the initial diagnosis of PV. He had a normal karyotype at polycythemic disease stage, t(11;14)(p13;q11.2) was newly detected at the time of fibrotic transformation. Therefore, it is likely that this clonal chromosomal abnormality was associated with progression of disease.
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Authors
Ji Hun Jeong, Jeong Yeal Ahn, Pil Whan Park, Yiel Hea Seo, Ja Young Seo, Jae Hoon Lee, Kyung Hee Kim,