Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2110318 | Cancer Genetics | 2015 | 5 Pages |
Abstract
We describe a unique case of a woman with acute myeloid leukemia with a new, previously undescribed translocation, t(11;18)(q23;q21.2), affecting the KMT2A (MLL) gene and resulting in an KMT2A(MLL)-ME2 fusion. This disease occurred secondarily following chemotherapy for a different acute myeloid leukemia with the recurrent genetic abnormality inv(16)(p13.1;q22). The secondary leukemia was treated with intensive chemotherapy without allogeneic hematopoietic cell transplantation. Complete remission lasting more than 10 years has been achieved with concurrent and sustained remission of the primary leukemia.
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Authors
TomáÅ¡ Szotkowski, Marie JaroÅ¡ová, Olga Zimmermannová, Claus Meyer, Rolf Marschalek, Jan Zuna, JaromÃr HubáÄek, Karel Indrák,