Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2111196 | Cancer Genetics and Cytogenetics | 2009 | 5 Pages |
Abstract
We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.
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Authors
Michael Mikulasovich, Amanda LeBlanc, Angela Scalise, Deepa Manwani, Alla Keyzner, Vesna Najfeld,