Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2111405 | Cancer Genetics and Cytogenetics | 2008 | 7 Pages |
Abstract
A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.
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Authors
Gwendoline Soler, Isabelle Radford, Claus Meyer, Rolf Marschalek, Chantal Brouzes, David Ghez, Serge Romana, Roland Berger,