NUP98–NSD1 fusion by insertion in acute myeloblastic leukemia

A case of NUP98–NSD1 gene fusion resulting from the insertion of a subtelomeric part of chromosome 11p15.4 within the subtelomeric part of 5q35 was detected in a child with acute myeloblastic leukemia. This new case illustrates the importance of using fluorescence in situ hybridization followed by reverse transcriptase–polymerase chain reaction techniques to detect abnormalities involving subtelomeric chromosomal regions.