| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2111722 | Cancer Genetics and Cytogenetics | 2007 | 5 Pages |
Abstract
A reciprocal t(X;12)(p11;p13) was found as the sole clonal abnormality in biphenotypic leukemia with myeloid and B-lymphoid differentiation. With fluorescence in situ hybridization analysis, the ETV6 gene (previously TEL) was found to be translocated intact to the derivative X chromosome; no MLL and BCR/ABL rearrangements were found. The patient achieved complete remission after induction chemotherapy. To our knowledge, this cytogenetic aberration has not been reported previously as a sole abnormality in hematological malignancies. Its presence may suggest an important role in the pathogenesis of biphenotypic leukemia.
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Authors
Kalliopi N. Manola, Vasileios N. Georgakakos, Theodore Marinakis, Chryssa Stavropoulou, George Paterakis, Nikolaos I. Anagnostopoulos, Gabriel E. Pantelias, Constantina Sambani,