| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2111758 | Cancer Genetics and Cytogenetics | 2007 | 4 Pages |
Abstract
A 49-year-old man, who had been diagnosed with chronic lymphocytic leukemia (CLL) in 2002, had a normal karyotype in his bone marrow. Trisomy 8 was demonstrated in his peripheral blood in 2005. Fluorescence in situ hybridization using an LSI CEP 8 probe performed on the archival bone marrow specimen showed three hybridization signals in 40% of 200 interphase cells scored. This confirmed that the trisomy 8 abnormality was present in both the blood and bone marrow samples. Trisomy 8 as the sole chromosomal abnormality in CLL is a very rare finding. The prognostic significance of trisomy 8 in CLL remains to be seen.
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Authors
Lai-Ching Lau, Su-Keyau Kee, Sim-Leng Tien, Boon-Chai Koh Mickey,