| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2111780 | Cancer Genetics and Cytogenetics | 2007 | 7 Pages |
Abstract
We report the case of a 62-year-old man who presented with splenomegaly, leukocytosis, anemia, and thrombocytopenia. Examination of the peripheral blood, bone marrow, and spleen revealed involvement by mantle cell lymphoma, with some blastoid features and an atypical phenotype. Spleen and bone marrow classical chromosome analysis followed by fluorescence in situ hybridization revealed a novel and unusual unbalanced variant of the t(11;14)(q13;q32) translocation, resulting in a complex derivative chromosome harboring the IGH/CCND1 fusion gene. This chromosome was designated as der(14)t(11;14)(q13;q32)t(11;14)(p11.1;p11.2).
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Authors
Malini Sathanoori, Sofia Shekhter-Levin, Stanley M. Marks, Steven H. Swerdlow,