| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2112354 | Cancer Letters | 2016 | 10 Pages |
Abstract
Our data demonstrate a topoisomerase-resistant phenotype of human MSCs that may at least in part be due to the stem cells' ability to efficiently remove DNA damage caused by these anticancer agents. The observed resistance of MSCs warrants further investigation of these cells as a potential therapeutic option for treating topoisomerase inhibitor-induced bone marrow damage.
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Cancer Research
Authors
Nils H. Nicolay, Alexander Rühle, Ramon Lopez Perez, Thuy Trinh, Sonevisay Sisombath, Klaus-Josef Weber, Peter Schmezer, Anthony D. Ho, Jürgen Debus, Rainer Saffrich, Peter E. Huber,