| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2112439 | Cancer Letters | 2015 | 9 Pages |
•With the development of genome and transcriptome sequencing technologies, lncRNAs have received increased attention.•LncRNAs are dysregulated in colorectal cancer (CRC) and closely related with tumorigenesis, metastasisand prognosis.•The review discusses the regulatory function of lncRNAs in CRC.•The review discusses the application of lncRNA as a biomarker for CRC diagnosis.
Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment.
