| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2112571 | Cancer Letters | 2014 | 8 Pages |
Abstract
Highlight•TGF-β circulating levels are not related to more advanced stage of HCC.•The inverse correlation TGF-β/E-cadherin supports the role of TGF-β in EMT.•E-cadherin, MMP-2 and VEGF are related to TGF-β activity.•These biomarkers could help to select candidates for receiving a TGF-β inhibitor.
TGF-β1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor.
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Authors
Francesco Dituri, Gabriella Serio, Doriana Filannino, Antonella Mascolo, Rodolfo Sacco, Erica Villa, Gianluigi Giannelli,