Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2112651 | Cancer Letters | 2014 | 9 Pages |
Abstract
This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Lynn M. Martin, Brian Marples, Thomas H. Lynch, Donal Hollywood, Laure Marignol,