| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2112654 | Cancer Letters | 2014 | 8 Pages |
•MicroRNAs are novel post-transcriptional regulators of gene expression.•MicroRNAs are aberrantly expressed in pancreatic cancer.•MicroRNAs play key roles in pancreatic cancer pathogenesis.•MicroRNAs can be exploited as novel diagnostic and prognostic biomarkers.•MicroRNAs can serve as novel targets for pancreatic cancer therapy.
Despite progress in recent years, pancreatic cancer still remains a major clinical challenge. Its incidence and mortality rates have been on consistent rise underscoring the critical need for novel diagnostic, prognostic and therapeutic tools for its effective management. Recent studies have demonstrated that microRNAs (miRNAs/miRs) are deregulated in a variety of malignancies, including pancreatic cancer, and play a significant role in the initiation, progression and metastasis. Furthermore, their vital involvement in the therapeutic resistance of cancer has also been established. Hence, there has been enormous interest worldwide in investigating the roles of miRNAs in pancreatic cancer pathogenesis and exploiting their utility for clinical benefit. In this review, we summarize current knowledge on the role of miRNAs in pancreatic cancer and discuss their potential use as diagnostic and prognostic biomarkers, and as novel targets for development of effective therapeutic strategies.
