| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2112707 | Cancer Letters | 2014 | 7 Pages |
Abstract
PurposesTo investigate whether miR-15a inhibits cell proliferation and epithelial–mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression.Methods and ResultsmiR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line.ConclusionmiR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.
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Authors
Shixiang Guo, Xuejun Xu, Yichen Tang, Chaobin Zhang, Jian Li, Yongsheng Ouyang, Jingfang Ju, Ping Bie, Huaizhi Wang,